| 应用 |
A Dnmt inhibitor that silences tumor suppressor genes. |
| 产品介绍 |
RG108是一种DNA甲基转移酶抑制剂，IC50为115 nM，不会引起共价酶的诱捕。 |
| 备注 |
RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes. |
| 生化机理 |
RG108 is a non-nucleoside DNA methyltransferase (Dnmt) inhibitor that blocks the enzyme active site. RG108 inhibits DNA methylation in human cancer cell lines without detectable toxicity in vitro. The compound demethylates and reactivates epigenetically silences tumor suppressor genes. |
| 别名 |
N-酞酰-L-色氨酸;N-邻苯二甲酰基-L-色氨酸;N-Phthalyl-L-tryptophan;RG 108;RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid |
