| 应用 |
Desloratadine是人H1受体拮抗剂。 |
| 产品介绍 |
Desloratadine is a potent and selective histamine H1-receptor agonist with a half life of 21-24 hours. Experiments suggest that this compound also exerts antioxidant effects in vitro. Other studies show that H1-receptor binding by desloratadine is reversible and that, over time, desloratadine dissociates from membrane H1-recepters. Desloratadine has also demonstrated the ability to block ICAM-1 upregulation and NFκB activation in primary bronchial and transformed respiratory epithelial cells in vitro. |
| 生化机理 |
It is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects. |
| 别名 |
脱羧氯雷他定;地氯雷他定;地洛他定;8-氯-6,11-二氢-11-(4-哌啶烯基)-5H-苯并[5,6]环庚基[1,2-b]吡啶;8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine |
