| 应用 |
抗肿瘤。 |
| 产品介绍 |
6-Thioguanine is a chemotherapy drug that demonstrates immunosuppressive, anti-neoplastic, and anti-cancer activities. This chemical is often used to treat leukemia and inflammatory diseases. Chemical produces dose-dependent inhibition of stimulated expression of TRAIL protein. |
| 生化机理 |
Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides.
Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia. |
| 别名 |
2-氨基-6-巯基嘌呤; 6-硫代鸟嘌呤; 2-氨基-6-巯嘌呤;2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol; 6-Mercaptoguanine |
