| 产品介绍 |
属呋喃香豆素类化合物。为棱柱状结晶（由乙醚）、长细针晶（由热水），易溶于氯仿，可溶于苯、乙醇、乙醚和苛性碱溶液，不溶于冷水。
Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway. |
| 生化机理 |
欧前胡素是p38、ERK路径的调控因子。欧前胡素增加BMP-2的表达(mRNA) ,体外研究证实欧前胡素增加体内骨质密度/体积和矿物化。 |
| 别名 |
欧前胡素;8-Isopentenyloxypsoralen;
9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one;
9-[(3-Methyl-2-buten-1-yl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one;
Ammidin
Marmelide
Marmelosin
NSC 402949 |
