Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle.
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