M.W 419.73 Formular C20H15ClN4.2HCl Solubility Soluble in DMSO at 10-20 mg/mL Purity >99% Biological Activity Vatalanib inhibited VEGF-induced phosphorylation (IC50's of 17 nM and 34 nM for HUVECs and CHO cells, respectively), blocked thymidine incorporation induced by VEGF in HUVECs (IC50 = 7.1 nM), prevented VEGF-induced HUVEC migration dose dependently (IC50 = 58 nM), and inhibited tumor cell proliferation with an IC50 of 17 uM and 18 uM for A431 and DU145 cells, respectively and sprout formation in rat aortas (IC50 = 675 nM). Synonym CGP-79787,PTK 787, ZK222584 Store at -20oC, Desiccate |