BML-SA646-0200 200 µl
BML-SA646-0050 50 µl
OX1R (also known as hypocretin receptor 1) is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B1. Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor, prepro-orexin. OX1R binds orexin A with ten-fold greater affinity than to orexin B. OX2R binds both ligands with similar affinities2, 3. Both OX1R and OX2R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.
OX1R is thought to transmit signals through the Gα11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels2, 3. The orexin system has been shown to be involved in the regulation of sleep and wakefulness states and OX1R knockout mice show defects in the regulation of REM sleep, among other phenotypic alterations4. In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain4. OX1R is expressed in both the central nervous system and peripheral locations such as gastrointestinal tissues, pancreas, and testis2.
Product Specification
Alternative Name: OX1R
Immunogen: Synthetic peptide corresponding to aa 256-269 of rat OX1R (orexin receptor 1).
Source/Host: From rabbit.
Specificity: Recognizes human, rat and mouse orexin receptor 1.
Application: Immunocytochemistry
Immunohistochemistry
Western Blot
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Long Term Storage: -20°C
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