BML-SL110-0025 25 mg
BML-SL110-0005 5 mg
A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G0/G1 transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.
Product Specification
Alternative Name: N-Hexanoyl-D-erythro-sphingosine
Formula: C24H47NO3
MW: 397.7
Purity: ≥98% (TLC)
Appearance: White waxy solid.
CAS: 124753-97-5
Solubility: Soluble in 100% ethanol (>25mg/ml) and DMSO (>50mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.