BML-EI263-0025 25 mg
BML-EI263-0005 5 mg AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
Product Specification
Alternative Name: 3-Hydroxy-4-nitrobenzylidenemalononitrile
Formula: C10H5N3O3
MW: 215.2
Purity: ≥98%
Appearance: Yellow solid.
CAS: 118409-62-4
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).
Long Term Storage: Ambient
Handling: Protect from light.
Store tightly sealed in the dark.
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