BML-EI345-0100 100 mg
BML-EI345-0020 20 mg
Apigenin is an antioxidant flavonoid. Has chemopreventive and antitumor  properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. Is a MAP-Kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. Induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels. Apigenin is a selective inhibitor of CK2. In WEHI 231 cells inhibition of CK2 by apigenin decreased the rate of IκBα turnover and nuclear levels of NF-κB (20 µM).
It blocks proliferation of Wnt-1 transfected cells and abrogates phosphorylation of β-catenin. In a rat model of glomerulonephritis, inhibition of CK2 by apigenin ameliorates renal dysfunction.
Product Specification
Formula: C15H10O5
MW: 270.3
Purity: ≥97% (TLC)
Appearance: light yellow to slightly brown powder
CAS: 520-36-5
Solubility: Soluble in  diluted potassium hydroxyde or DMSO, slightly soluble in 100% ethanol (hot). Insoluble in water.
Long Term Storage: Ambient
Hazard: IRRITANT.
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