3-hydroxyanthranilate 3,4-dioxygenase antibody
Cat.#: S0948
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P46952
Mol Weight: 32.56kDa
Size: 100ug

Description
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq]

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:500-1:3000

Species Reactivity
Human

Other species have not been tested

Products Data

Sample(30ug of whole cell lysate)
A:Hep G2
12% SDS PAGE
diluted at 1:500

Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 228 of Human HAAO

Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.

Alternative Names
HAAO antibody, 3-HAO antibody, HAO antibody, 3-hydroxyanthranilate 3,4-dioxygenase antibody, 3-hydroxyanthranilic acid dioxygenase antibody