Activin Receptor Type IA(ACVR1)Antibody(Center N99)
Cat.#: T2016
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q04771
Mol Weight: 57kDa
Size: 100ug

Description
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 is an activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:100~500
ELISA: 1:1,000

Species Reactivity
Human, Mouse

Products Data

 
Western blot analysis of anti-ACVR1 Pab in mouse brain tissue lysate. ACVR1(arrow) was detected using the purified Pab.

Specificity
This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ACVR1.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
ACVR1 antibody, ACTRI antibody, ACVR1A antibody, ACVRLK2 antibody, ALK2 antibody, FOP antibody, SKR1 antibody, TSRI antibody, Activin receptor type-1 antibody, TGF-B superfamily receptor type I antibody

Description References
Kan, L. et al. Stem Cells. January; 27(1): 150?56(2009).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Welt, C.K., Curr Opin Obstet Gynecol 14(3):317-323 (2002).
Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002).
Chapman, S.C., et al., Mol. Endocrinol. 15(4):668-679 (2001).
Schulte, K.M., et al., Horm. Metab. Res. 32(10):390-400 (2000).