ALS2CR2 Antibody(C-term L289)
Cat.#: T2032
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: Q9C0K7
Mol Weight: 47kDa
Size: 100ug

Description
ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.

Recommended Applications
WB, ELISA

Applications and Recommended Dilution Factors
WB: 1:50~100
ELISA: 1:1,000

Species Reactivity
Human

Products Data

Western blot analysis of ALS2CR2 (arrow) using ALS2CR2 Antibody (C-term L289) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALS2CR2 gene (Lane 2) (Origene Technologies).

Specificity
This ALS2CR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281~311 amino acids from the C-terminal region of human ALS2CR2.

Storage Condition and Buffer
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Alternative Names
STRADB antibody, ALS2CR2 antibody, CALS-21 antibody, ILPIP antibody, ILPIPA antibody, MGC102916 antibody, PAPK antibody, STE20-related kinase adapter protein beta antibody, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein antibody, CALS-21 antibody, ILP-interacting protein antibody, Pseudokinase ALS2CR2 antibody

Description References
Nishigaki, K., et al., J. Biol. Chem. 278(15):13520-13530 (2003).
Sanna, M.G., et al., J. Biol. Chem. 277(34):30454-30462 (2002).
Hadano, S., et al., Genomics 71(2):200-213 (2001).