产品描述
Alpha Actinin antibody
Cat.#: S1429
Rabbit Polyclonal Antibody
Clone ID: polyclonal
Swiss Prot: P12814
Mol Weight: 103.08kDa
Size: 100ul
Description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:500-1:3000
Species Reactivity
Human
Other species have not been tested
Products Data
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Specificity
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 220 and 350 of Human ACTN1
Storage Condition and Buffer
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative. Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Purified by antigen-affinity chromatography.
Alternative Names
ACTN1 antibody, FLJ40884 antibody, FLJ54432 antibody, Alpha-actinin-1 antibody, Alpha-actinin cytoskeletal isoform antibody, F-actin cross-linking protein antibody, Non-muscle alpha-actinin-1 antibody
