APP(Abeta40)antibody
Cat.#: 2238-1
Rabbit Monoclonal Antibody
Clone ID: EP1876Y
Swiss Prot: P05067
Mol Weight: 4kDa
Size: 100ul

Description
Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain and blood vessel walls. Amyloid Beta A4 (Aβ4) protein has been found to be the principal constituent of senile plaques of ADs patients (1-2). APP (Abeta40) is proteolytically cleaved to generate the 4 kDa Aβ4 protein. Two variants of Aβ4 can be detected; Aβ-40 short-tailed and Aβ-42 long-tailed (3-4).

Recommended Applications
WB

Applications and Recommended Dilution Factors
WB: 1:1,000 - 10,000

Species Reactivity
Human

Cross reactivity determined by western blot only.

Products Data 

 

A. Western blot analysis on 5ng of recombinant protein using anti-APP (Abeta40) RabMAb (cat. # 2238-1).
B. Western blot analysis on A. Abeta40, B. Abeta42 and C. Abeta38 using anti-APP (Abeta40) RabMAb (cat. # 2238-1).

Specificity
A synthetic peptide corresponding to residues in human APP (Abeta40) was used as immunogen. This antibody specifically recognizes Amyloid Beta Protein (Aβ4) variant Aβ-40.

Storage Condition and Buffer
Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Alternative Names
APP antibody, AAA antibody, ABETA antibody, ABPP antibody, AD1 antibody, APPI antibody, CTFgamma antibody, CVAP antibody, PN2 antibody, C31 antibody, Gamma-CTF(50) antibody

Description References
1. Glenner, G. G, et al. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., et al. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Dovey, H., et al. (1993) NeuroReport 4, 1039-1042
4. Vigo-Pelfrey, C., et al (1993) J. Neurochem. 61, 1965-1968