产地：usa
货号：F0503
中文名:氟尿嘧啶,5-氟尿嘧啶
英文名:Fluorouracil ,5 FU,5-fluorouracil 
说明:白色结晶或粉末。略溶于水，微溶于乙醇。190～200℃(13.3Pa)升华。282～283℃(分解)。最大吸收波长(0.1mol/L盐酸中)265～266(ε 7070)。中等毒性，半数致死量(大鼠，经口)230mg/kg。有腐蚀性
尿嘧啶5位上的氢为氟所代换的一种碱基类似物。如果投与动物，可和尿嘧啶同样地被吸收而阻碍细胞的增殖。其作用是在生物体内核糖基化和磷酸化，变成氟尿嘧啶核苷酸，认为此酸由于能抑制胸腺嘧啶核苷酸合成酶，因而可抑制DNA的合成。另外由于能形成三磷酸氟尿嘧啶，也为RNA所摄取，所以可合成异常的蛋白质。
水溶性: 12.2 g/L 20°C
Description
Frequently Asked Questions Live Chat and Frequently Asked Questions  are available for this Product.
Biochem/physiol Actions A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
Sigma相关产品资料：
Sigma  F6627  5-Fluorouracil  ≥99% (TLC), powder
Synonym: 2,4-Dihydroxy-5-fluoropyrimidine, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, 5-FU
CAS Number: 51-21-8
Linear Formula: C4H3FN2O2
Molecular Weight: 130.08
Beilstein Registry Number: 127172
EC Number: 200-085-6
MDL number: MFCD00006018
PubChem Substance ID: 24278439
性质
assay ≥99% (TLC)
form powder
color white
mp 282-286 °C (dec.)(lit.)
solubility 1  M NH4OH: soluble
              DMSO/DMF: soluble
              methanol: soluble
Gene Information human ... TYMS(7298)