产地：usa
货号：B5507
名称：Bleomycin sulfate from Streptomyces verticillus
别名: Blenoxane, Bleo, Blexane
相关类型 Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal,
Antineoplastic and Immunosuppressive Antibiotics, Antitumor Agents, Apoptosis and Cell Cycle, B, Bioactive Small Molecules, Cancer Research, Cell Biology, Chemical Structure Class, DNA Modification / Repair, DNA Synthesis Inhibitors, DNA metabolism, Genetic Marker Selection, Glycopeptides, Interferes with DNA Synthesis, Mechanism of Action, Spectrum of Activity
more...
form crystalline
color white
solubility H2O: soluble20 mg/mL
cation traces Cu: <0.1%
storage temp. 2-8°C
Application
Recommended for use as a selection agent at 10-100 μg/ml.
Other Notes
A mixture of bleomycin sulfate salts
Biochem/physiol Actions
An antineoplastic antibiotic isolated from Streptomyces verticillus. Binds to DNA, inhibits DNA synthesis and causes DNA scissions at specific base sequences. Needs to bind oxygen and a metal ion such as copper or iron to cleave DNA. Highly selective cleavage of RNA. Inducer and regulator of apoptosis in a variety of cells. Inhibits tumor angiogenesis.