Streptozocin
别名: N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin
分子量: 265.22
CAS号: 18883-66-4
Application
Streptozocin is used to induce Type 1 diabetes for medical research.
General description
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
相关类型 Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,
Bioactive Small Molecules, Cell Biology, Cell Signaling Enzymes, Interferes with DNA Synthesis, Mechanism of Action, NO Donors, Nitric Oxide Donors, Nitric Oxide Metabolism, Nitric Oxide and Cell Stress, S
assay ≥75% α-anomer basis
≥98% (HPLC)
form powder
color white to off-white
mp 121 °C (dec.)(lit.)
storage temp. −20°C
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