Product Specification
Alternative Name: N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide . 2HCl
Formula: C20H20BrN3O2S·2HCl
MW: 519.2
Purity: 99% (TLC)
Appearance: White to off-white solid.
CAS: 127243-85-0
MeltingPoint: 141-143°C
Solubility: Soluble in DMSO (25mg/ml), methanol and 50% ethanol/water (20mg/ml).
Shipping: AMBIENT
Long Term Storage: +4°C
Use/Stability: Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 4 months in DMSO.
Replaces Prod. #: ALX-270-017
Cell permeable potent and selective inhibitor of cAMP- and cGMP-dependent protein kinases (PKA, Ki=48nM, and PKG) and protein kinase Cµ (PKCµ). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibited. Also inhibits Ca2+/calmodulin-dependent protein kinase II, casein kinase I and myosin light chain kinase. Induces apoptosis. Concentration range for cultured cells 30-100μM: osteoblastic cells, renal proximal tubule cells and Xenopus oocytes.