Product Specification
Alternative Name: 1-(5-Isoquinolinesulfonyl)homopiperazine . 2HCl, Fasudil
Formula: C14H17N3O2S . 2HCl
MW: 364.3
Purity: 98%
Appearance: Off-white solid.
CAS: 103745-39-7
MeltingPoint: >250°C
MI: 14: 3942
Solubility: Soluble in water (>20mg/ml), methanol or DMSO.
Shipping: AMBIENT
Long Term Storage: +4°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Replaces Prod. #: ALX-270-071
Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.