Replaces Prod. #: ALX-300-131
Selective inhibitor of protein myristoylation in cells, able to distinguish myristoylation from palmitoylation. Metabolic activation in cultured cells (0.5 mM) appears to be required. Myristoylation takes place on glycine residues at the N-terminus of proteins and provides a strong membrane anchor for the modified proteins, many of which require myristoylation for full activity. Blocks p56lck mediated signal transduction and inhibits Varicella-zoster virus replication.
Product Specification
Alternative Name: 2-Hydroxy-tetradecanoic acid
Formula: C14H28O3
MW: 244.4
Purity: ≥97% (TLC)
Appearance: White to off-white solid.
CAS: 2507-55-3
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: +4°C
Use/Stability: Stable for at least 2 years after receipt when stored at +4°C. Stock solutions are stable for up to 3 months at -20°C.
Miscellaneous/General: p56lck and other members of the Src family of protein-tyrosine kinases as well as the αo, αi and αz subfamilies of G protein α subunits are covalently modified by N-myristoylation of their amino-terminal glycine residues. Myristoylation aids in membrane anchoring and is a requirement for full activity.