Product Specification Formula: C43H69NO12 MW: 792 Purity: ≥95% (HPLC) Appearance: Off-white solid CAS: 11011-38-4 Source/Host: Isolated from Streptomyces sp. Solubility: Soluble in DMSO (25mg/ml) Shipping: AMBIENT Long Term Storage: -20°C Use/Stability: Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Hazard: HARMFUL. Replaces Prod. #: ALX-380-005 Ascomycin is a close structural analog of FK506 and is a potent immunosuppressant. It binds to FKBP (FK506-binding protein) and suppresses its proline rotamase activity. The ascomycin-FKBP complex inhibits calcineurin, a type 2B phosphatase.
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