Replaces Prod. #: ALX-350-281 Cardiotonic steroid specific Na+/K+-ATPase inhibitor. More potent than ouabain (Prod. No. BML-CM109). Induces cell differentiation. Induces apoptosis in U937 and HL-60 cells by activation of AP-1 via a MAPK pathway that involves JNK. Regulates Tiam1 gene. Down regulates expression of 14-3-3 protein. Product Specification Alternative Name: (3β,5β)-3,14-Dihydroxybufa-20,22-dienolide, 5β,20(22)-Bufadienolide-3β,14-diol Formula: C24H34O4 MW: 386.5 Purity: ≥98% (TLC) Appearance: White to off-white solid. CAS: 465-21-4 MI: 14: 1471 RTECS: EI2962500 Solubility: Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml, warm). Shipping: SHIPPED ON BLUE ICE Long Term Storage: -20°C Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. Hazard: VERY TOXIC.