The presence of the small heat shock protein αB-crystallin in ballooned neurons, characteristic of Pick’s and Creutzfeld-Jacob disease, and in Rosenthal fibers, characteristic of Alexander’s disease, suggests a role in the aggregation and remodelling of neurofilaments in neurodegenerative disease. Both mono- and poly-ubiquitinylated conjugates of αB-crystallin have been observed in Rosenthal fibers. Phosphorylated αB-crystallin interacts with FBX4, an F-box-containing protein that is a component of the ubiquitin-protein isopeptide ligase SCF (Skp1/Cul1/F-box), implicating αB-crystallin in the ubiquitin-proteasome pathway.
Product Specification
Immunogen: Synthetic peptide corresponding to aa 1-10 of human αB-crystallin.
Source/Host: From rabbit.
Specificity: Recognizes human αB-crystallin
Application: Immunohistochemistry
Western Blot
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Long Term Storage: -20°C