Cytochrome P-450 2E1(CYP2E1) is principally found in the liver, and is ethanol-inducible. It catalyzes many biotransformations. In rat brain CYP2E1 is localized to cells within the substantia nigra and in striatial blood vessels where a possible role in the pathology of oxidative stress, believed to underlie nigral degeneration has been proposed. Recently, increased expression of human CYP2E1 mRNA, along with that of several other CYP genes, has been found in the uterine endometrium of patients treated with tamoxifen.
Product Specification
Alternative Name: CYP2E1
Immunogen: Synthetic peptide corresponding to the C-terminus of hepatic human, rat, rabbit, and mouse CYP2E1.
Source/Host: From rabbit.
Specificity: Recognizes human, mouse and rat CYP2E1.
Application: Immunohistochemistry (frozen sections; paraffin sections)
Western Blot
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Long Term Storage: -20°C