Replaces Prod. #: ALX-350-119
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II) by covalently modifying a conserved active-site histidine. Precursor to TNP-470. Exhibits antitumor activity in estrogen-induced pituitary adenoma. Antineoplastic. Anti-infective.
Product Specification
Alternative Name: Fumidil B, Fumadil B, TNP-470
Formula: C26H34O7
MW: 458.6
Purity: ≥95% (TLC)
Appearance: Off-white to light yellow solid.
CAS: 23110-15-8
MI: 14: 4286
Source/Host: Isolated from Aspergillus fumigatus.
Solubility: Soluble in DMSO (25mg/ml) or diluted aqueous bases; slightly soluble in methanol or other alcoholic solvents; insoluble in water.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solutions with pH >9.0 or pH <5.0.
Hazard: HARMFUL.
Handling: Keep under inert gas.
Protect from light and oxygen.