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Replaces Prod. #: ALX-385-022
Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes.
Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).
Product Specification
Alternative Name: 5,6,7-Trihydroxyflavone
Formula: C15H10O5
MW: 270.2
Purity: ≥98% (TLC)
Appearance: Yellow to yellow-green crystalline powder.
CAS: 491-67-8
MI: 14: 942
Solubility: Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water.
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Subject to oxidation.
Hazard: IRRITANT.
Handling: Protect from light.