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Cell permeable, potent and selective p38 MAP kinase inhibitor (IC50=30 nM). Inhibits p38α and ß, but not γ and δ isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. A useful tool for dissecting the role of p38 in signaling pathways. Induces apoptosis.
Product Specification
Alternative Name: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Formula: C20H14FN3O
MW: 331.3
Purity: ≥98% (TLC)
Appearance: Pale yellow solid.
CAS: 152121-30-7
Solubility: Soluble in methanol, DMSO or acetone; slightly soluble in ethyl acetate.
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Protect from light.
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