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Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.
Product Specification
Alternative Name: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
Formula: C23H23N3O3
MW: 389.4
Purity: ≥95% (HPLC)
Appearance: White to off-white solid.
CAS: 208260-29-1
Solubility: Soluble in DMSO (200mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 3 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Keep under inert gas.
Protect from light.
产品描述
