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17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity.
Inducer of macroautophagy.
Product Specification
Alternative Name: 17-(Allylamino)-17-desmethoxygeldanamycin
Identity: Identity determined by 1H-NMR.
Formula: C31H43N3O8
MW: 585.7
Purity: ≥98% (TLC)
Appearance: Red to dark red powder.
CAS: 75747-14-7
Source/Host: Semisynthetic derivative from geldanamycin.
Solubility: Soluble in DMSO (>20mg/ml) or 100% ethanol (10mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Handling: Protect from light.