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Less toxic, more potent synthetic derivative of geldanamycin. Inhibitor of angiogenesis. Inhibitor of heat shock protein 90 (HSP90). Cytotoxic against multiple cancer cell types and inhibits angiogenesis. Inducer of apoptosis with higher antitumor activity than 17-AAG (Prod. No. BML-EI308). 17-DMAG or Geldanamycin reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes.
Product Specification
Alternative Name: 17-[2-(Dimethylamino)ethyl]amino-17-desmethoxygeldanamycin, NSC 707545
Formula: C32H48N4O8
MW: 616.8
Purity: ≥98% (TLC)
Appearance: Purple solid.
CAS: 150270-08-9
Solubility: Soluble in 100% ethanol (10mg/ml) or DMSO (>25mg/ml).
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Store, as supplied, at -20°C for up to1 year- Store solutions at -20°C for up to 3 months.
Handling: Protect from light.