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Replaces Prod. #: ALX-385-023
PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2 µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems.
Product Specification
Alternative Name: MEK Inhibitor
Formula: C16N13NO3
MW: 267.3
Purity: ≥95% (HPLC)
Appearance: Pale yellow solid
CAS: 167869-21-8
Solubility: Soluble in DMSO (6.5mg/ml); 25mg/ml in anhydrous DMSO), methanol, dichlormethane and 100% ethanol (0.6mg/ml)
Shipping: AMBIENT
Long Term Storage: -20°C
Hazard: HARMFUL.
Handling: Protect from light.