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Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant. Inhibits lipid peroxidation in a variety of experimental systems including cultured brain microvessel endothlial cells, Cu2+ treated monocyclic THP1 cells and LLC-PK1 cell layers where it blocks F2 isoprostane production. Prevented organ damage in intestinal cold storage, preservation and reperfusion injury.
Product Specification
Alternative Name: 21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
Formula: C37H50N6O2 . C4H4O4
MW: 726.9
Purity: ≥98% (TLC)
Appearance: White solid.
CAS: 153190-29-5
Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (20mg/ml). Insoluble in water.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Hygroscopic.