订购电话:021-51870956 在线QQ:470003480 快来www.haoranbio.com体验在线订购给您带来的快捷和方便吧! Replaces Prod. #: ALX-290-001 Members of the Ras superfamily of G proteins, γ-subunits of heterotrimeric G proteins and the α-subunit of cGMP phosphodiesterase from retinal rods are all carboxyl methylated at carboxy-terminal S-farnesylcysteine residues. AFC specifically inhibits the S-farnesylcysteine methyl transferase (Km=20 µM) in cell free extracts and in whole cells. It inhibits carboxyl methylation of p21ras platelet Rap15 and the γ-subunit of transducin. It blocks receptor-mediated signal transduction in platelets and neutrophils not by inhibiting the methyltransferase, but possibly by inhibiting capacitative Ca2+ entry. Product Specification Formula: C20H33NO3S MW: 367.5 Purity: ≥98% (TLC) Appearance: Pale yellow oil. CAS: 135304-07-3 Solubility: Soluble in DMSO (25mg/ml), methanol or 100% ethanol (25mg/ml). Shipping: AMBIENT Long Term Storage: -20°C Handling: Keep under inert gas.