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Novel cell-permeable p53 reactivating agent. Restores sequence-specific DNA binding and the active conformation to mutant p53 (in 13 of 14 p53 mutants tested) in vitro and in living cells. Induces apoptosis in human tumor cell lines and displays antitumor activity in mice.
Product Specification
Alternative Name: 2,2-bis(Hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one, 2,2-bis(Hydroxymethyl)-3-quinuclidinone
Formula: C9H15NO3
MW: 185.2
Purity: ≥98% (TLC)
Appearance: White to off-white solid.
CAS: 5608-24-2
Solubility: 25mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 10mg/ml soluble in water.
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. We do not recommend storing aqueous solutions for more than one day.