货号：BML-PI127-0100  100 µg
Cell permeable, potent and selective proteasome inhibitor originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity. More potent inhibitor of the chymotrypsin-like activity of the proteasome than lactacystin (Prod. No. BML-PI104). Blocks also trypsin-like and PGPH activities of the proteasome. Regulates antigen presentation at non-toxic doses. Effectively inhibits NF-κB activation in vitro and potently blocks inflammation in vivo in the mouse ear edema assay.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by Epoxomicin activates autophagy.
Product Specification
Formula: C28H50N4O7
MW: 554.7
Purity: ≥95% (HPLC)
Appearance: White solid.
CAS: 134381-21-8
MI: 14: 3630
Solubility: Soluble in DMSO (15mg/ml) or dichloromethane:methanol (9:1); insoluble in water.
Shipping: AMBIENT
Long Term Storage: -20°C
Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling: Avoid freeze/thaw cycles.
Protect from light.
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