BML-PW9795-0100 100 µl
BML-PW9795-0025 25 µl
Ubiquitin-specific protease 15 (USP15) contains the highly conserved Cys and His boxes present in all members of the UBP family of deubiquitinating enzymes. USP15 shares 60.5% sequence identity and 76% sequence similarity with the human homolog (UNP/Unph/USP4) of the mouse Unp proto-oncogene. USP15 can be co-purified with the human CSN complex. Detailed analysis reveals a novel Zinc (Zn)-finger in USP15 and related USPs. Mutation of a single conserved cysteine residue in the predicted Zn binding motif results in the loss of USP15 capability to degrade poly-Ub substrates, indicating that the Zn-finger is essential for the cleavage of poly-Ub chains.
Product Specification
Alternative Name: Ubiquitin-specific protease 15
Immunogen: Recombinant human USP15 (aa 724-952).
Source/Host: From rabbit.
Specificity: Recognizes human and mouse USP15.
Application: Western Blot
Shipping: SHIPPED ON BLUE ICE
Long Term Storage: -20°C  
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