产品描述
别名: 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride Fingolimod hydrochloride
经验分子式（希尔表示法） C19H33NO2 · HCl
分子量 343.93
5, 25 mg in glass bottle
FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.
| Related Categories | Bioactive Small Molecule Alphabetical Index, F,Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics, |
| assay | ≥98% (HPLC) |
| form | powder |
| storage condition | desiccated |
| color | white to beige |
| solubility | water: 10 mg/mL, clear |
| storage temp. | −20°C |
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