产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | A multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase。 |
| 产品介绍 | KW-2449能较强地抑制Flt3，IC50为6.6 nM，对FGFR1，Bcr-Abl和Aurora A的抑制性适中，而对 PDGFRβ，IGF-1R，EGFR则无抑制性。 |
| 生化机理 | KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. KW 2449 displays potent inhibition of growth effects on leukemia cells with FLT3 mutations via inhibition of the FLT3 kinase, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis. KW 2449 induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis in FLT3 wild-type human leukemia. KW 2449 contributes to release of the resistance by the simultaneous down-regulation of BCR/ABL and Aurora kinases in imatinib-resistant leukemia. |
| 别名 | KW 2449; KW2449；[4-[2-(1H-吲唑-3-基)乙烯基]苯基]-1-哌嗪基甲酮;KW 2449;KW2449；[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone |
