产品描述
| 溶解性 | Soluble in DMSO (≥20 mg/ml), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
| 应用 | A potent and selective FAK (focal adhesion kinase) inhibitor. |
| 产品介绍 | PF-573228是一种ATP竞争性的FAK抑制剂，无细胞试验中IC50为4 nM，作用于FAK比作用于Pyk2，CDK1/7 和 GSK-3β选择性高~50到250倍。 |
| 合法信息 | Sold for only research purposes |
| 备注 | PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. |
| 生化机理 | PF 573228 is a potent and selective FAK (focal adhesion kinase) inhibitor (IC50 = 4 nM). PF 573228 displays 50-250-fold selectivity over other protein kinases. PF 573228 decreases focal adhesion kinase (FAK) turnover in vitro. PF 573228 also blocks serum and fibronectin-directed migration. |
| 别名 | PF 573228; 6-[(4-((3-(甲磺酰基)苄基)氨基)-5-三氟甲基嘧啶-2-基)氨基]-3,4-二氢-1H-喹啉-2-酮;PF573228;PF 573228;6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one; PF-228;FAK Inhibitor II |
