产品描述
| 沸点 | 493.54° C at 760 mmHg |
| 熔点 | 193.32°C |
| 折光率 | 1.68 |
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3600 |
| 应用 | An effective and selective inhibitor of Src family kinases |
| 产品介绍 | PP2(AGL 1879) 是可逆的ATP竞争性的Src家族抑制剂，对p56lck，p59fynT，Hck和Src的IC50分别为4，5，5和100 nM。 |
| 生化机理 | PP 2 is an effective and selective inhibitor of c-Src family kinases. The inhibitor has been shown to inhibit Lck, FynT, phosphorylation of focal adhesion kinase (FAK) and potently inhibits Hck, Lck (p56) and Fyn (p59). Additionally, PP 2 was reported to inhibit tyrosone kinase-dependent TcR-induced T cell proliferation. PP 2 studies indicate that this agent has demonstrated the ability to activate ERK 1, ERK 2 and p38. Research suggests that PP 2 may be useful to help identify c-Src family member substrates. MCF-7 cell research shows that PP 2 down regulates the expression of both enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 (PRDX3), and induces apoptosis. PP 2 is an inhibitor of casein kinase I δ and RICK. |
| 别名 | AGL 1879;PP 2;PP-2; 3-(4-氯苯基)-1-叔丁基-1H-吡唑并[3,4-d]嘧啶-4-胺;AGL 1879;PP 2;PP-2; PP 2 (enzyme inhibitor); Src kinase inhibitor PP2; 3-(4-Chlorophenyl)-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
