产品描述
| 熔点 | 315.5-317.5°C |
| 溶解性 | Soluble in DMSO (55 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), 1% DMSO/30% polyethylene glycol/1% Tween 80 (15 mg/ml at 25 °C), and THF (sparingly). |
| 存贮条件 | 储存温度2-8℃ |
| 应用 | Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog. An inhibitor of LPS-induced TNFαrelease. |
| 产品介绍 | Pomalidomide抑制LPS诱导的TNF-alpha释放， IC50为13 nM。 |
| 备注 | Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM. |
| 生化机理 | Pomalidomide is tumor necrosis factor-α inhibitor and a new immunomodulator with an IC50 of 1 μM.Pomalidomide is thalidomide derivative that displays inhibition of LPS-induced TNFα release. Shows immunomodulator and anticancer effects. |
| 别名 | CC-4047;3-氨基-N-(2,6-二氧代-3-哌啶基)邻苯二甲酰亚胺;泊马度胺;TNF-alpha抑制剂;IMiD 3;1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide;4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
