产品描述
| 溶解性 | 25°C: DMSO |
| 存贮条件 | 储存温度2-8℃ |
| 产品介绍 | Hydroxyfasudil(HA1100)是Fasudil的代谢物，对ROCK1和ROCK2的IC50分别为120nM和170nM，还是血管舒张剂。 |
| 生化机理 | Fasudil (1-10 μM) and hydroxyfasudil (0.3-10 μM) significantly prevented endothelin-induced cardiomyocyte hypertrophy [2]. Hydroxyfasudil significantly attenuated serotonin (IC)-induced vasoconstriction of SA (-7 +/- 1% vs. 2 +/- 1%, p < 0.01). Coronary I/R significantly impaired coronary vasodilation to acetylcholine after I/R (SA, p < 0.05; and A, p < 0.01 vs. before I/R) and L-NMMA further reduced the vasodilation, whereas hydroxyfasudil completely preserved the responses. |
| 别名 | HA-1100;HA 1100;HA1100;HA-1100;HA 1100;HA1100; 5-((hexahydro-1h-1,4-diazepin-1-yl)sulfonyl)-1(2h)-isoquinolinone; |
