HMN-214

HMN-214

产品参数

货号 规格 操作
H125770-5mg 咨询
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服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

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产品描述产品描述
  • 分子式 C22H20N2O5S
  • 分子量424.48

属性

溶解性
  • DMSO 12 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
  • 存贮条件 储存温度-20°C

    描述

    应用 A potent inhibitor of Polo-like kinase and a broad-spectrum anti-tumor agent
    产品介绍 HMN-214(IVX214)是PLK1抑制剂,平均IC50为0.12 μM。
    生化机理 HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk) with IC50 of 118 nM. HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drug-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase. HMN-176 (3 μM) down-regulates the expression of the multi-drug resistance gene (MDR1), due to the disturbance of NF-Y transcription factor binding to the MDR1 promoter. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formation of Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes.
    别名 HMN214;HMN 214; (E)-4-(2-(2-(N-乙酰基-N-((4-甲氧基苯基)磺酰)氨基)苯基)乙烯基)吡啶 1-氧化物;;IVX-214;IVX 214;IVX-214;IVX214;(e)-4-(2-(2-(n-acetyl-n-((4-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide
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