产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 备注 | GSK461364 inhibits purified Plk1 with Ki of 2.2 nM. It is more than 1000-fold selective against Plk2/3. Phase 1. |
| 生化机理 |
GSK-461364A is a potent small molecule Polo-like kinase 1 (PLK1) inhibitor with a Ki of 2.2 nM. GSK-461364A is an ATP-competitive inhibitor of Plk1 and forms a rapidly reversible complex with Plk1. |
| 别名 | 5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-((R)-1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide;5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-((R)-1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide |
