Genz-644282

Genz-644282

产品参数

货号 规格 操作
G126864-10mg 咨询
G126864-5mg 咨询
G126864-25mg 咨询
G126864-100mg 咨询
G126864-50mg 咨询
更多货号咨询>>
关闭

服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

普通会员 普通会员
推荐产品推荐产品
产品描述产品描述
  • 分子式 C22H21N3O5
  • 分子量407.42

属性

沸点 ~665.5 °C at 760 mmHg
熔点 >240 °C
折光率 1.65
溶解性 25°C: DMSO
存贮条件 储存温度-20°C
密度 1.3000

描述

产品介绍 Genz-644282是非喜树碱类拓扑异构酶I抑制剂,IC50为1.2 nM,有抗肿瘤活性。
生化机理

Description:
IC50 Value: 1.2 nM [1]
Genz-644282 [8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate of non-Camptothecin topoisomerase I inhibitor for antitumor agents.
in vitro: Genz-644282 demonstrated potent cytotoxic activity with a median IC(50) of 1.2?nM (range 0.2-21.9?nM) [1]. Limited cross-resistance to Genz-644282 was also found in the Top1 knockdown colon cancer (HCT116) and breast cancer (MCF7) cell lines and in human adenocarcinoma cells (KB31/KBV1) that overexpress (P-glycoprotein, ABCB1), a member of the ATP-binding cassette family of cell surface transport proteins known to confer MDR [3].
in vivo: Genz-644282 at its MTD (4?mg/kg) induced maintained complete responses (MCR) in 6/6 evaluable solid tumor models. At 2?mg/kg Genz-644282 induced CR or MCR in 3/3 tumor models relatively insensitive to topotecan, but there were no objective responses at 1?mg/

别名 Genz644282;Genz 644282;Genz644282;Genz 644282;2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one
店铺 店铺 咨询留言 咨询留言 热线电话 热线电话