Ro3280

Ro3280

产品参数

货号 规格 操作
R127227-1mg 咨询
R127227-25mg 咨询
R127227-5mg 咨询
更多货号咨询>>
关闭

服务地域:全国

属性:产地:上海; 品牌:阿拉丁 ;货期:现货

上海阿拉丁生化科技股份有限公司

普通会员 普通会员
推荐产品推荐产品
产品描述产品描述

属性

溶解性
  • DMSO mg/mL
  • Water mg/mL
  • Ethanol mg/mL
  • 存贮条件 储存温度-20°C

    描述

    备注 RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with IC50 of 3 nM.
    生化机理

    Description:
    IC50 Value: 3 nM (PLK1) [1]
     RO3280 exhibits potent antiproliferative activity in a wide range of cancer cell lines, and shows strong anti-tumor activities in an in vivo HT-29 colorectal xenograft mouse model.
    Difluoro-analog 7 (RO3280) gave the best results in both enzymatic (PLK1, IC50 = 3 nM) and cellular (lung cancer cell line H82, EC50 = 6 nM) assays. RO3280 was evaluated for its in vivo antitumor activity in a series of mouse xenograft models, of which the HT-29 colorectal cancer cell line is representative. RO3280 displayed robust antitumor activity ranging from 72% tumor growth inhibition when dosed once weekly at 40 mg/Kg, to complete tumor regression when dosed more frequently.
     

    别名 Ro5203280;Benzamide, 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-;Ro5203280;Benzamide, 4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-
    店铺 店铺 咨询留言 咨询留言 热线电话 热线电话