产品描述
| 溶解性 |
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| 存贮条件 | 储存温度-20°C |
| 应用 | An allosteric, specific reversible inhibitor of Eg5 |
| 产品介绍 | Ispinesib (SB-715992)是高亲和性的KSP(HsEg5)特异性抑制剂，Ki为1.7 nM。 |
| 生化机理 | Ispinesib is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. |
| 别名 | 伊斯平斯;SB-715992;SB 715992;SB715992;N-(3-Aminopropyl)-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylmethyl)-2-quinazolinyl]-2-methylpropyl]-4-methylbenzamide |
