沸点 | ~646.9° C at 760 mmHg |
熔点 | 246.28° C |
折光率 | 1.73 |
溶解性 |
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存贮条件 | 储存温度-20°C |
密度 | 1.4000 |
应用 | A DNA-PK inhibitor, and antitumor agent in vitro. |
产品介绍 | KU-57788(NU7441)是DNA-PK选择性抑制剂,IC50为14 nM,对mTOR,PI3K,ATM和ATR的抑制性较弱。 |
生化机理 | NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells . |
别名 | KU 57788; NU-7441; KU57788; NU7441; NU 7441;8-(4-二苯并噻吩基)-2-(4-吗啉基)-4H-1-苯并吡喃-4-酮;KU 57788; NU-7441;KU57788;NU7441;NU 7441;8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |