溶解性 | Soluble in DMSO (10 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
存贮条件 | 储存温度2-8℃ |
应用 | A Topo I inhibitor |
产品介绍 | Irinotecan是一种Topoisomerase I抑制剂,作用于LoVo细胞和HT-29细胞,IC50分别为15.8 μM和5.17 μM。 |
备注 | Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
生化机理 | (+)-Irinotecan is an isomer of the Topo I inhibitor Irinotecan |
别名 | 伊立替康;依立替康; (S)-4,11-二乙基-3,4,12,14-四氢-4-羟基-3,14-二氧代-1H-吡喃并[3',4':6,7]中氮茚并[1,2-b]喹啉-9-基 1,4'-联哌啶-1'-羧酸酯;(+)-Irinotecan;CPT-11;1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester |